Repbase Reports
2007, Volume 7, Issue 4
April 30, 2007
Copyright © 2001-2016 - Genetic Information Research Institute
ISSN# 1534-830X
Page 145

IS4EU-1_NV

A family of autonomous IS4EU transposons - a consensus.

Submitted:
29-Apr-2007 		Accepted:
30-Apr-2007
Key Words:
IS4EU; DNA transposon; Interspersed Repeat; IS4EU-1_NV
Source:
Nematostella vectensis 		Organism:
Nematostella vectensis 		Taxonomy:
Eukaryota; Metazoa; Cnidaria; Anthozoa; Zoantharia; Actiniaria; Edwardsiidae; Nematostella
[1] Authors:
Kapitonov,V.V. and Jurka,J.
Title:
IS4EU, a novel superfamily of eukaryotic DNA transposons.
Journal:
Repbase Reports 7(4), 145-145 (2007)
Abstract:
DNA transposons from the IS4EU superfamily are characterized by the TA target site duplications. These transposons are wide spread in metazoans, including fish, frogs, lancelet, sea urchins, sea squirts, insects and cnidarians. Autonomous IS4EU transposons encode two proteins: the IS4EU-TR transposase, which is similar to the IS4-like bacterial transposases, and the ISEU-EX DNA exonuclease (lambda-like exonuclease). Based on the conservation of both proteins in highly divergent transposons, is is clear that they are necessary for transpositions. IS4EU-1_NV is a consensus sequence of a very young family of autonomous IS4EU transposons that were active in the starlet sea anemone genome in a last few million years. The IS4EU-1_NV transposon is characterized by 14-bp imperfect terminal inverted repeats, TA target site duplications, and it encodes two proteins: (i) the 538-aa transposase, IS4EU-1_NV1p, composed of the THAP DNA-binding N-terminal domain and catalytic "DDE" domain, which is conserved in all IS4EU transposases, and (ii) the 1034-aa IS4EU-1_NV2p exonuclease (its C-terminal part contains also two PHD zinc-finger and the Ulp1-like cysteine protease domains). Comments and questions send to Vladimir Kapitonov.
Derived:
[1] (Consensus)
Download Sequence - Format:
IG, EMBL, FASTA
References:

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